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Sirius T3 analytical services brochure

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Sirius T3 analytical services brochure

Brochure

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Pion’s physicochemical analysis services help identify promising small molecule drug candidates and support earlier formulation and development decisions.

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Dissolve Macro Orange

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Sirius T3 analytical services brochure

Brochure

Pion Analytical Services offers physicochemical characterization to help you identify the most promising small molecule drug candidates rapidly and efficiently so you can make informed decisions about candidate selection & formulation earlier in development.

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Brochure

Dissolve Macro Orange
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Sirius T3 analytical services brochure
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BioFLUX & MacroFLUX
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Solid Oral Dosage Sample Preparation
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Understanding Drug Diffusion in Peptide Hydrogels
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Nanocellulose Exfoliation by High Pressure Homogenization
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Webinar: What the Flux? Part 1
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pKa Measurements in 18 Minutes The SiriusT3 Fast UV pKa Method
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Evaluating Amorphous Solid Dispersions Using Dissolution- Permeation Assays
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AstraZeneca SCISSOR Summary of Journal of Controlled Release article 2025
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Liquid Phase Exfoliation of Graphite to Graphene
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Absorption-Driven Formulation Development
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Evaluating the Impact of Hyaluronidase on Subcutaneous mAb Formulations Using the SCISSOR N3 Platform
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Predicting Bioequivalence During Generic Drug Formulation
Publication
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability
Publication
Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
Publication
Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model
Publication
PAMPA – a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux – optimized design (pOD-PAMPA)
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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques
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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-2
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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-1
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Evaluating In Situ Forming Gels for Long-Acting Injectables
Publication
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
Publication
Drug ionization and physicochemical profiling
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Absorption using the  PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)
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Micro Intrinsic Dissolution Rate (IDR) System
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Improved prediction of food effect on oral drug absorption
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Advancing Oral Drug Development with In Vitro Dissolution and Absorption Tools
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SiriusT3 Product Brochure
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miniDT Small Volume Dissolution Testing
Application Notes
Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis
Webinar
De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine
Webinar
Simulating prodrug biotransformation in vitro - Conserving enzymatic activity within the SCISSOR N3 platform
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Pion Analytical Services SCISSOR
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Advancing in vitro-in vivo relationships: Steps in establishing an in vitro response for GLP-1 receptor agonists
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Nanoforming - the single pill technology
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Performance Validation Test DPVT for USP 2 PQ for Pion DissoSpec
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The Pion DissoSpec QC Dissolution Monitoring System
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Long Acting Injectable Adapters, USP 2
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Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches
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3 Benefits of Conducting Simultaneous Dissolution and Permeability Tests
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4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development
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Carbon Nanotube Application Test Data and Results
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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing
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DissoPRO Software v3.6
Webinar
Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Subcutaneous Injection Site Simulator Assay
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Predictor Software
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Service agreement plans
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SiriusT3 Lite - A PhysChem Platform
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Predictive power and operational use of SCISSOR to streamline SC biologics drug development
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The impact of colloids and nanoparticles on intestinal drug absorption
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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study
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Micro DeBEE
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Pion's BEE Brand Homogenizers - The Ultimate Research Tool
Application Notes
Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
Whitepaper
Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
Webinar
Introduction to Pion's BEE brand high-pressure homogenizers
Poster
Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
Application Notes
Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
Application Notes
Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
Application Notes
Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
Application Notes
Using NaOH and NaCl instead of KOH and KCl
Application Notes
Introduction to log P and log D measurement using PionT3
Application Notes
Measuring log P of samples that are hard to dissolve in water and octanol
Application Notes
The Determination of Solubility - Pion CheqSol Explained
Application Notes
The use of cosolvent pKa assays for poorly soluble compounds
Application Notes
Measurement of Extreme pKas
Application Notes
Solubility and Supersaturation - A Brief Introduction
Video
Scissor N3 overview and demo
Application Notes
Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
Application Notes
Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
Application Notes
Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
E-book
How to Achieve Efficient & Consistent Particle Size Reduction e-book
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Homogenization For Cannabis e-book
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Advantages of Pion BEE brand Homogenizers for the Pharmaceutical Industry e-book
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7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book
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Reversal of IDO-mediated cancer immune suppression
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Control of Oral Bioavailability by Particle Sizes
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Method for preparing propofol emulsion for vascular injection
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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
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Nanoparticle Formation
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DeBEE 4000
Webinar
Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.
Poster
Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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MiniDeBEE
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Nano DeBEE
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DeBEE 2000
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