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SCISSOR N3 In Vitro Injection Site Simulator Infographic

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SCISSOR N3 In Vitro Injection Site Simulator Infographic

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Explore challenges in predicting SC drug behavior and how advanced in vitro models can improve insights into bioavailability and IVIVC earlier in development.

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SCISSOR N3 In Vitro Injection Site Simulator Infographic

Infographic

Explore the Future of Predictive SC Drug Development

Predicting how subcutaneous (SC) drugs behave in the body remains one of the biggest challenges in biologics development. Unlike oral drugs, establishing reliable in vitro–in vivo correlations (IVIVC) for SC therapies is complicated by variable tissue environments, injection site behavior, and bioavailability.

Our latest infographic explores why this gap exists—and how advanced in vitro models are helping researchers generate more predictive insights earlier in development.

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Infographic

Dissolve Macro Orange
Application Notes
Improving Absorption Prediction Using Integrated Dissolution– Permeation Testing and Mechanistic In Silico Modeling
Infographic
Sirius T3 Physicochemical measurements infographic
Infographic
SCISSOR N3 In Vitro Injection Site Simulator Infographic
Case Study
De-risking Formulation Development: Using the MacroFLUX System to Predict Human Outcomes of KinetiSol Processed Etravirine
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PAMPA Analytical Services Brochure
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SDi2 Analytical Services Brochure
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Sirius T3 analytical services brochure
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BioFLUX & MacroFLUX
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MicroFLUX Brochure
Application Notes
Solid Oral Dosage Sample Preparation
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PrepEngine Brochure
Webinar
Webinar: What the Flux? Part 2
Video
Understanding Drug Diffusion in Peptide Hydrogels
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Nanocellulose Exfoliation by High Pressure Homogenization
Webinar
Webinar: What the Flux? Part 1
Application Notes
pKa Measurements in 18 Minutes The SiriusT3 Fast UV pKa Method
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Evaluating Amorphous Solid Dispersions Using Dissolution- Permeation Assays
Video
AstraZeneca SCISSOR Summary of Journal of Controlled Release article 2025
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Liquid Phase Exfoliation of Graphite to Graphene
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Absorption-Driven Formulation Development
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Evaluating the Impact of Hyaluronidase on Subcutaneous mAb Formulations Using the SCISSOR N3 Platform
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Predicting Bioequivalence During Generic Drug Formulation
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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability
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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
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Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model
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PAMPA – a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux – optimized design (pOD-PAMPA)
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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques
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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-2
Webinar
Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-1
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Evaluating In Situ Forming Gels for Long-Acting Injectables
Publication
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
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Drug ionization and physicochemical profiling
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Absorption using the  PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)
Brochure
Micro Intrinsic Dissolution Rate (IDR) System
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Improved prediction of food effect on oral drug absorption
Webinar
Advancing Oral Drug Development with In Vitro Dissolution and Absorption Tools
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SiriusT3 Product Brochure
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miniDT Small Volume Dissolution Testing
Application Notes
Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis
Webinar
De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine
Webinar
Simulating prodrug biotransformation in vitro - Conserving enzymatic activity within the SCISSOR N3 platform
Brochure
Pion Analytical Services SCISSOR
Application Notes
Advancing in vitro-in vivo relationships: Steps in establishing an in vitro response for GLP-1 receptor agonists
Webinar
Nanoforming - the single pill technology
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Performance Validation Test DPVT for USP 2 PQ for Pion DissoSpec
Brochure
The Pion DissoSpec QC Dissolution Monitoring System
User Guide
Long Acting Injectable Adapters, USP 4
User Guide
Long Acting Injectable Adapters, USP 2
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Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches
Whitepaper
3 Benefits of Conducting Simultaneous Dissolution and Permeability Tests
Whitepaper
4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development
Application Notes
Carbon Nanotube Application Test Data and Results
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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing
Brochure
DissoPRO Software v3.6
Webinar
Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction
Webinar
Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Brochure
Subcutaneous Injection Site Simulator Assay
Webinar
Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Brochure
Predictor Software
Brochure
Service agreement plans
Brochure
SiriusT3 Lite - A PhysChem Platform
Webinar
Predictive power and operational use of SCISSOR to streamline SC biologics drug development
Webinar
The impact of colloids and nanoparticles on intestinal drug absorption
Publication
Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Publication
Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study
Brochure
Micro DeBEE
Webinar
Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
Whitepaper
Pion's BEE Brand Homogenizers - The Ultimate Research Tool
Application Notes
Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
Whitepaper
Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
Webinar
Introduction to Pion's BEE brand high-pressure homogenizers
Poster
Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
Application Notes
Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
Application Notes
Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
Application Notes
Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
Application Notes
Using NaOH and NaCl instead of KOH and KCl
Application Notes
Introduction to log P and log D measurement using PionT3
Application Notes
Measuring log P of samples that are hard to dissolve in water and octanol
Application Notes
The Determination of Solubility - Pion CheqSol Explained
Application Notes
The use of cosolvent pKa assays for poorly soluble compounds
Application Notes
Measurement of Extreme pKas
Application Notes
Solubility and Supersaturation - A Brief Introduction
Video
Scissor N3 overview and demo
Application Notes
Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
Application Notes
Scissor as a platform for the analysis of non-protein subcutaneous formulations
Application Notes
Understanding excipient effect in vitro using the Pion Scissor
Application Notes
Considerations on the Controlled Release of Injectable Insulin Using Scissor
Application Notes
Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
E-book
How to Achieve Efficient & Consistent Particle Size Reduction e-book
E-book
Homogenization For Cannabis e-book
E-book
Advantages of Pion BEE brand Homogenizers for the Pharmaceutical Industry e-book
E-book
7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book
Publication
Reversal of IDO-mediated cancer immune suppression
Publication
Control of Oral Bioavailability by Particle Sizes
Publication
Method for preparing propofol emulsion for vascular injection
Publication
Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
Publication
Nanoparticle Formation
Brochure
DeBEE 4000
Webinar
Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
Webinar
Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.
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