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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

Applications Note

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The subcutaneous injection site simulator was designed and validated to better mimic the human subcutaneous extracellular matrix environment.

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Dissolve Macro Orange

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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

Applications Note

This application note will present data for a range of pharmaceutical motifs examined in the SCISSOR, and describe modifications made to the assay format to increase the time in which an API can be monitored from 1 day to 1 week, expanding the range of applications for this in vitro method.

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Applications Note

Dissolve Macro Orange
Webinar
Predictive power and operational use of SCISSOR to streamline SC biologics drug development
Webinar
The impact of colloids and nanoparticles on intestinal drug absorption
Publication
Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
Publication
Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study
Brochure
Micro DeBEE
Webinar
Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
Whitepaper
Pion's BEE Brand Homogenizers - The Ultimate Research Tool
Applications Note
Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
Whitepaper
Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
Webinar
Introduction to Pion's BEE brand high-pressure homogenizers
Poster
Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
Applications Note
Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
Applications Note
Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
Applications Note
Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
Applications Note
Using NaOH and NaCl instead of KOH and KCl
Applications Note
Introduction to log P and log D measurement using PionT3
Applications Note
Measuring log P of samples that are hard to dissolve in water and octanol
Applications Note
The Determination of Solubility - Pion CheqSol Explained
Applications Note
The use of cosolvent pKa assays for poorly soluble compounds
Applications Note
Measurement of Extreme pKas
Applications Note
Solubility and Supersaturation - A Brief Introduction
Video
Scissor N3 overview and demo
Applications Note
Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
Applications Note
Scissor as a platform for the analysis of non-protein subcutaneous formulations
Applications Note
Understanding excipient effect in vitro using the Pion Scissor
Applications Note
Considerations on the Controlled Release of Injectable Insulin Using Scissor
Applications Note
Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
E-book
How to Achieve Efficient & Consistent Particle Size Reduction e-book
E-book
Homogenization For Cannabis e-book
E-book
Advantages of BEE Homogenizers for the Pharmaceutical Industry e-book
E-book
7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book
Publication
Reversal of IDO-mediated cancer immune suppression
Publication
Control of Oral Bioavailability by Particle Sizes
Publication
Method for preparing propofol emulsion for vascular injection
Publication
Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
Publication
Nanoparticle Formation
Brochure
DeBEE 4000
Webinar
Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
Webinar
Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.
Poster
Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
Brochure
MiniDeBEE
Brochure
Nano DeBEE
Brochure
DeBEE 2000
Video
Dissolution Testing
Video
PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
Poster
Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
Poster
Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
Poster
Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
Poster
Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
Poster
Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Poster
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Poster
Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
Poster
Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
Poster
Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
Poster
Penetration Enhancer Effect of Sucrose Esters
Poster
Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
Poster
Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
Poster
Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
Poster
Drug Permeation in Skin PAMPA and Franz Cell Model
Poster
In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
Poster
Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
Poster
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
Poster
Nanoparticle Formulation of Gresiofulvin
Poster
Universal Potentiometric Sensors Protein Binding
Poster
In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
Poster
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
Poster
Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
Poster
Supersaturation and Transmembrane Flux of Meloxicam
Poster
Universal Potentiometric Sensors Food Matrixes
Poster
Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
Poster
Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
Poster
Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Poster
Skin-PAMPA: Fast Prediction of Skin Penetration
Poster
Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
Poster
Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
Poster
In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Poster
Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
Poster
Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Poster
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Poster
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Poster
Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
Poster
Using Skin PAMPA For Transdermal Patch Testing
Poster
In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
Poster
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
Poster
Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids
Poster
Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds
Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
Poster
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Poster
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
Poster
Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes
Poster
Utilization of pH-Metric Titration
Poster
Application of Skin Pampa to Cosmetic Solvent Screening
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