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Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches

Application Notes

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Advanced in vitro testing of nicotine pouches using Pion systems for real-time dissolution and permeability analysis under physiological conditions.

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Dissolve Macro Orange

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Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches

Application Notes

Dissolution and Permeability Testing for Nicotine Pouches

This application brief highlights advanced in vitro methods for evaluating nicotine release and absorption from oral tobacco-derived nicotine (OTDN) pouches. Featuring Pion’s MicroDISS Profiler™ and MicroFLUX™ systems, the brief outlines how small-volume dissolution and permeability testing simulate physiological conditions to generate accurate, real-time data. These insights help support product development, quality control, and potential in vitro/in vivo correlation (IVIVC) for regulatory submissions.

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Application Notes

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