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Improving Absorption Prediction Using Integrated Dissolution– Permeation Testing and Mechanistic In Silico Modeling

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Improving Absorption Prediction Using Integrated Dissolution– Permeation Testing and Mechanistic In Silico Modeling

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Explore how FLUX dissolution–permeation testing and Predictor™ mechanistic modelling can provide deeper insight into oral absorption and formulation performance

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Dissolve Macro Orange

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Improving Absorption Prediction Using Integrated Dissolution– Permeation Testing and Mechanistic In Silico Modeling

Application Notes

Discover how integrated dissolution–permeation testing and mechanistic in-silico modelling can provide deeper insight into oral drug absorption. This application note features MicroFLUX™ and BioFLUX™ case studies demonstrating how FLUX data and Predictor™ can support in vivo absorption predictions and formulation assessment.

Application Notes

Dissolve Macro Orange
Application Notes
Improving Absorption Prediction Using Integrated Dissolution– Permeation Testing and Mechanistic In Silico Modeling
Infographic
Sirius T3 Physicochemical measurements infographic
Infographic
SCISSOR N3 In Vitro Injection Site Simulator Infographic
Case Study
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pKa Measurements in 18 Minutes The SiriusT3 Fast UV pKa Method
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Evaluating Amorphous Solid Dispersions Using Dissolution- Permeation Assays
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Liquid Phase Exfoliation of Graphite to Graphene
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Absorption-Driven Formulation Development
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Evaluating the Impact of Hyaluronidase on Subcutaneous mAb Formulations Using the SCISSOR N3 Platform
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Predicting Bioequivalence During Generic Drug Formulation
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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability
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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
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Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model
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PAMPA – a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux – optimized design (pOD-PAMPA)
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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques
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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-2
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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-1
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Evaluating In Situ Forming Gels for Long-Acting Injectables
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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
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Drug ionization and physicochemical profiling
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Absorption using the  PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)
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Micro Intrinsic Dissolution Rate (IDR) System
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Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis
Webinar
De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine
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Simulating prodrug biotransformation in vitro - Conserving enzymatic activity within the SCISSOR N3 platform
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Pion Analytical Services SCISSOR
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3 Benefits of Conducting Simultaneous Dissolution and Permeability Tests
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4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development
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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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The impact of colloids and nanoparticles on intestinal drug absorption
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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study
Brochure
Micro DeBEE
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
Whitepaper
Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
Poster
Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
Application Notes
Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
Application Notes
Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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