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The use of cosolvent pKa assays for poorly soluble compounds

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The use of cosolvent pKa assays for poorly soluble compounds

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Titrations in several different solvent / water ratios, the pKas of water-insoluble compounds can be derived using the Yasuda-Shedlovsky extrapolation.

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Dissolve Macro Orange

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The use of cosolvent pKa assays for poorly soluble compounds

Application Notes

The ionization constant or pKa is a solution property of a compound. The formation of a precipitate during a pKa acid/base titration therefore prevents the accurate measurement of pKa.

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