Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores

Purpose.  The aim of the study was to assess how thin PAMPA membrane barriers could be made before they become too fragile or leaky through water pores.

Conclusion.  It was shown that antipyrine can have an elevated PAMPA permeability value (from 1 to 5 x10^-6 cm/s) in the plates with the thinnest barrier (BD), but it was clear that the plates were too leaky through water pores.  This would limit the application to lipophilic molecules.