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Recently developed Zero Intercept Method (ZIM) enabling, for example, in situ concentration monitoring of free API being released from nanoparticles was applied to determine solubility and dissolution of gresiofulvin formulated as nanosuspension. The effect of formulation was also studied through miniaturized dissolution-permeability setup (µFLUX) to determine if nanosuspension formulation improves flux of the griseofulvin through artificial membrane.
