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Purpose. This research investigated the applicability and limitations of a novel approach for measuring intrinsic dissolution rates (IDR) of very small quantities of compounds introduced as powders to buffered solutions and compare these results to disk IDR obtained using the traditional Wood’s apparatus.
Conclusion. Powder IDR measurements can be used in the early stages of drug development, as they use up to 1000 times less API than the traditional Wood’s rotating disk apparatus and are much faster, too. Application of the powder dissolution method to compounds with solubility >1 mg/mL requires additional study.
