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Improved prediction of food effect on oral drug absorption

Application Notes

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Discover a more accurate approach to food effect prediction by combining dissolution and permeation to better reflect clinical outcomes.

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Dissolve Macro Orange

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Improved prediction of food effect on oral drug absorption

Application Notes

Predicting food effect based on dissolution alone can be misleading.

Our latest application note shows why evaluating both dissolution and permeation is essential—especially for SL-E and SL-U compounds. Using FaRLS theory and a Remibrutinib case study, we demonstrate how increased fed-state solubility doesn’t always translate to increased absorption—and why dissolution–permeation data aligns more closely with clinical outcomes.

Learn how an integrated approach using MicroFLUX™, MiniFLUX™, BioFLUX™, and MacroFLUX™ can improve food-effect prediction and strengthen development decisions.

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Application Notes

Dissolve Macro Orange
Application Notes
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