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PAMPA Analytical Services Brochure

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Pion’s PAMPA analysis services determine passive membrane permeability to support early-stage drug candidate evaluation and development.

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Parallel Artificial Membrane Permeability Assay

Pion Analytical Services offers Parallel Artificial Membrane Permeability Assay (PAMPA) analysis services to determine passive membrane permeability.

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Solid Oral Dosage Sample Preparation

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Webinar: What the Flux? Part 2

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Understanding Drug Diffusion in Peptide Hydrogels

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Nanocellulose Exfoliation by High Pressure Homogenization

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Webinar: What the Flux? Part 1

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pKa Measurements in 18 Minutes The SiriusT3 Fast UV pKa Method

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Evaluating Amorphous Solid Dispersions Using Dissolution- Permeation Assays

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AstraZeneca SCISSOR Summary of Journal of Controlled Release article 2025

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Liquid Phase Exfoliation of Graphite to Graphene

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Absorption-Driven Formulation Development

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Evaluating the Impact of Hyaluronidase on Subcutaneous mAb Formulations Using the SCISSOR N3 Platform

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Predicting Bioequivalence During Generic Drug Formulation

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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability

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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates

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Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

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PAMPA – a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux – optimized design (pOD-PAMPA)

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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-2

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Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-1

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Evaluating In Situ Forming Gels for Long-Acting Injectables

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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.

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Drug ionization and physicochemical profiling

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Absorption using the PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)

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Micro Intrinsic Dissolution Rate (IDR) System

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Improved prediction of food effect on oral drug absorption

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Advancing Oral Drug Development with In Vitro Dissolution and Absorption Tools

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SiriusT3 Product Brochure

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miniDT Small Volume Dissolution Testing

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Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis

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De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine

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Simulating prodrug biotransformation in vitro - Conserving enzymatic activity within the SCISSOR N3 platform

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Pion Analytical Services SCISSOR

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Advancing in vitro-in vivo relationships: Steps in establishing an in vitro response for GLP-1 receptor agonists

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Nanoforming - the single pill technology

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Performance Validation Test DPVT for USP 2 PQ for Pion DissoSpec

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The Pion DissoSpec QC Dissolution Monitoring System

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Long Acting Injectable Adapters, USP 4

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Long Acting Injectable Adapters, USP 2

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Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches

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3 Benefits of Conducting Simultaneous Dissolution and Permeability Tests

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4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development

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Carbon Nanotube Application Test Data and Results

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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing

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DissoPRO Software v3.6

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Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Subcutaneous Injection Site Simulator Assay

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Predictor Software

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Service agreement plans

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SiriusT3 Lite - A PhysChem Platform

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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

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The impact of colloids and nanoparticles on intestinal drug absorption

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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study

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Micro DeBEE

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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis

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Pion's BEE Brand Homogenizers - The Ultimate Research Tool

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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX

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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

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Introduction to Pion's BEE brand high-pressure homogenizers

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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements

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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules

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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy

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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

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Using NaOH and NaCl instead of KOH and KCl

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Introduction to log P and log D measurement using PionT3

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Measuring log P of samples that are hard to dissolve in water and octanol

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The Determination of Solubility - Pion CheqSol Explained

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The use of cosolvent pKa assays for poorly soluble compounds

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Measurement of Extreme pKas

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Solubility and Supersaturation - A Brief Introduction

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Scissor N3 overview and demo

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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations

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Scissor as a platform for the analysis of non-protein subcutaneous formulations

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Understanding excipient effect in vitro using the Pion Scissor

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Considerations on the Controlled Release of Injectable Insulin Using Scissor

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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules

E-book

How to Achieve Efficient & Consistent Particle Size Reduction e-book

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Homogenization For Cannabis e-book

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Advantages of Pion BEE brand Homogenizers for the Pharmaceutical Industry e-book

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7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book

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Reversal of IDO-mediated cancer immune suppression

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Control of Oral Bioavailability by Particle Sizes

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Method for preparing propofol emulsion for vascular injection

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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment

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Nanoparticle Formation

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DeBEE 4000

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Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools

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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.

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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride