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SDi2 Analytical Services Brochure

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SDi2 Analytical Services Brochure

Brochure

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High-resolution visible and UV imaging to investigate physical processes at the solid-liquid interface during solid dose drug dissolution.

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Dissolve Macro Orange

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SDi2 Analytical Services Brochure

Brochure

Solid Dose Surface Dissolution Imaging

Pion Analytical Services offers next-generation, high-resolution, visible and UV imaging to investigate the physical processes occurring  at the solid-liquid interface during solid dose drug dissolution.

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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability
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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
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Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model
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Evaluating In Situ Forming Gels for Long-Acting Injectables
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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
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Drug ionization and physicochemical profiling
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Absorption using the  PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)
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Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis
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De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine
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Service agreement plans
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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