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Evaluating In Situ Forming Gels for Long-Acting Injectables

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Evaluating In Situ Forming Gels for Long-Acting Injectables

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Evaluate in situ forming gels for long-acting injectables with in vitro excipient comparisons to accelerate subcutaneous formulation development.

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Dissolve Macro Orange

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Evaluating In Situ Forming Gels for Long-Acting Injectables

Application Notes

In situ forming gels provide sustained drug release by transitioning from a liquid to a gel after subcutaneous injection, creating a depot for controlled API delivery. Traditional in vitro methods often fail to accurately predict their performance.

In this study, the SCISSOR™ (Subcutaneous Injection Site Simulator) platform compared five gel formulations of the same small-molecule API within a tissue-mimicking matrix. Using HPLC, imaging, and turbidity analysis over seven days, SCISSOR differentiated release profiles, stability, and gelation behavior, providing mechanistic insights and enabling data-driven selection of optimal formulations for long-acting injectable development.

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Application Notes

Dissolve Macro Orange
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