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Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

Applications Note

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It was demonstrated that flux measurements provide more in-depth understanding of supersaturated systems than solute concentration measurements alone.
Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

Applications Note

It was demonstrated that flux measurements provide more in-depth understanding of supersaturated systems than solute concentration measurements alone. This study used miniaturized dissolution – permeation apparatus (μFLUX) to compare flux of itraconazole (Figure 1) from several formulations for which in-vivo rat PK data were available. The goal of the study was to evaluate the formulation benchmarking ability of the instrumental setup.

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