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Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane
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Applications Note
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It was demonstrated that flux measurements provide more in-depth understanding of supersaturated systems than solute concentration measurements alone.
Applications Note
It was demonstrated that flux measurements provide more in-depth understanding of supersaturated systems than solute concentration measurements alone. This study used miniaturized dissolution – permeation apparatus (μFLUX) to compare flux of itraconazole (Figure 1) from several formulations for which in-vivo rat PK data were available. The goal of the study was to evaluate the formulation benchmarking ability of the instrumental setup.