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The CheqSol method accurately determines the kinetic and intrinsic solubilities of ionizable compounds. It generates detailed information about the extent and duration of supersaturation and a pH-solubility profile from a single, highly automated assay which takes less than 2 hours. This application note provides a brief overview of the technique and should be read alongside Application Note 08/12, Solubility and Supersaturation —A Brief Introduction, which describes some terminology associated with solubility determination.
