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AN07 the Pion GI Dissolution Assay
Applications Note
An understanding of the dissolution and precipitation behaviour of active pharmaceutical ingredients is of fundamental importance in designing formulation approaches for successful drug delivery. The Pion GI Dissolution Assay has been designed as a formulation tool to conduct low volume, multi pH assays to give insight into how the dissolution of a drug is influenced by changes in pH1. By incorporating different excipients in the assay, methods of maintaining enhanced levels of drug in solution can be investigated to maintain supersaturation and avoid precipitation issues. Additionally, the assay can accommodate a lipidsink to further mimic drug absorption.