Assay Expert

Predicting Bioequivalence During Generic Drug Formulation

Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability

Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates

Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

PAMPA – a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux – optimized design (pOD-PAMPA)

Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-2

Food effect and beyond: Understanding complex in vivo interactions through biorelevant dissolution-permeation assays-Day-1

Evaluating In Situ Forming Gels for Long-Acting Injectables

The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.

Drug ionization and physicochemical profiling

Absorption using the  PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)

Micro Intrinsic Dissolution Rate (IDR) System

Improved prediction of food effect on oral drug absorption

Advancing Oral Drug Development with In Vitro Dissolution and Absorption Tools

SiriusT3 Product Brochure 2025

miniDT Small Volume Dissolution Testing

Demonstrating the Excipient Effect In Vitro for Subcutaneous Pre-Clinical Formulation Analysis

De-Risking development: Guiding formulation strategy with macroflux to predict human outcomes of kinetisol processed etravirine

Simulating prodrug biotransformation in vitro - Conserving enzymatic activity within the SCISSOR N3 platform

Pion Analytical Services SCISSOR

Advancing in vitro-in vivo relationships: Steps in establishing an in vitro response for GLP-1 receptor agonists

Nanoforming - the single pill technology

Performance Validation Test DPVT for USP 2 PQ for Pion DissoSpec

The Pion DissoSpec QC Dissolution Monitoring System

Long Acting Injectable Adapters, USP 4

Long Acting Injectable Adapters, USP 2

Dissolution and Permeation Testing of Oral Tobacco-Derived Nicotine (OTDN) Pouches

3 Benefits of Conducting Simultaneous Dissolution and Permeability Tests

4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development

Carbon Nanotube Application Test Data and Results

Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing

DissoPRO Software v3.6

Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction

Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

Subcutaneous Injection Site Simulator Assay

Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

Predictor Software

Service agreement plans

SiriusT3 Lite - A PhysChem Platform

Predictive power and operational use of SCISSOR to streamline SC biologics drug development

The impact of colloids and nanoparticles on intestinal drug absorption

Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study

Micro DeBEE

Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis

Pion's BEE Brand Homogenizers - The Ultimate Research Tool

Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX

Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

Introduction to Pion's BEE brand high-pressure homogenizers

Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements

Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules

Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy

Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

Using NaOH and NaCl instead of KOH and KCl

Introduction to log P and log D measurement using PionT3

Measuring log P of samples that are hard to dissolve in water and octanol

The Determination of Solubility - Pion CheqSol Explained

The use of cosolvent pKa assays for poorly soluble compounds

Measurement of Extreme pKas

Solubility and Supersaturation - A Brief Introduction

Scissor N3 overview and demo

Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations

Scissor as a platform for the analysis of non-protein subcutaneous formulations

Understanding excipient effect in vitro using the Pion Scissor

Considerations on the Controlled Release of Injectable Insulin Using Scissor

Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules

How to Achieve Efficient & Consistent Particle Size Reduction e-book

Homogenization For Cannabis e-book

Advantages of Pion BEE brand Homogenizers for the Pharmaceutical Industry e-book

7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book

Reversal of IDO-mediated cancer immune suppression

Control of Oral Bioavailability by Particle Sizes

Method for preparing propofol emulsion for vascular injection

Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment

Nanoparticle Formation

DeBEE 4000

Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools

Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.

Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride

MiniDeBEE

Nano DeBEE

DeBEE 2000

Dissolution Testing

PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root

Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

Penetration Enhancer Effect of Sucrose Esters

Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies

In Situ Solubility and Dissolution of Concentrated Solutions