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Detection of poor acid resistance of enteric coats using the SDI

Detection of poor acid resistance of enteric coats using the SDI

Poster

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UV surface imaging was able to detect poor acid resistance of an enteric coat. Within 1 minute, changes were observed in the coat.
Detection of poor acid resistance of enteric coats using the SDI

Poster

Currently, the acid resistance of the applied coat is determined by dissolution in a compendial dissolution apparatus with 0.1M Hydrochloric acid. Typically such methods require a prolonged running time (e.g. 2 hours) to understand the effect of prolonged exposure to acid and to establish a suitable solution concentration that can be measured. Also, it is not possible to determine were the tablet defects are (i.e. the embossed region).

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