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Detection of poor acid resistance of enteric coats using the SDI
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Poster
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UV surface imaging was able to detect poor acid resistance of an enteric coat. Within 1 minute, changes were observed in the coat.
Poster
Currently, the acid resistance of the applied coat is determined by dissolution in a compendial dissolution apparatus with 0.1M Hydrochloric acid. Typically such methods require a prolonged running time (e.g. 2 hours) to understand the effect of prolonged exposure to acid and to establish a suitable solution concentration that can be measured. Also, it is not possible to determine were the tablet defects are (i.e. the embossed region).