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Purpose The aim of this poster was to study the impact of several simulated lung fluid (SLF) media on the physicochemical properties of a selected group of inhaled drugs. Physicochemical properties such as pKa, log P, solubility and dissolution rates were measured at different conditions using protic and aprotic salts in phospholipid and surfactant systems to observe the impact of the media on the physicochemical properties of the drug. Sample properties were also compared with a standard phosphate buffer medium system.
