SCISSOR N3 Product Sheet

The SCISSOR N3 advances the Pion SubCutaneous Injection Site Simulator in vitro model capability for investigating the release performance of subcutaneous formulations under simulated physiological conditions. It assesses the risk and performance of subcutaneously administered drugs including biologics, peptides and small molecule. Simulating the stress conditions and environmental transitions that can lead to aggregation and precipitation of the API or poor in vivo release performance, it allows investigation of the API with the extracellular matrix, monitors the pH change upon injection, and identifies optimal excipient conditions. The SCISSOR N3 is the only commercially available solution that bridges the gap between standard dissolution and solubility results and in vivo Pharmacokinetics (PK) studies.