By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. View our Privacy Policy for more information.
When a poorly water-soluble active pharmaceutical ingredient (API) is formulated to enhance its dissolution, additives, such as surfactants, polymers and cyclodextrins have an effect not only on dissolution profile, but also on flux through the membrane. In order to fully understand these effects on flux, the driving force of membrane transport cannot be simplified to the total concentration gradient.
