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A biphasic dissolution assay has been developed to mimic dissolution and absorption within the human gastrointestinal tract(GIT). The pH and composition of the aqueous phase can be adjusted to simulate GI conditions. The passage of drug into the lipid phase simulates the absorption into the gut wall. Biphasic dissolution experiments involve many steps, and can be difficult to perform using conventional dissolution apparatus. The protocols described here take advantage of robotics and automation to ensure well-designed, reproducible and successful experiments.
