Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

Predictor Software

Service agreement plans

SiriusT3 Lite - A PhysChem Platform

Predictive power and operational use of SCISSOR to streamline SC biologics drug development

The impact of colloids and nanoparticles on intestinal drug absorption

Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study

Micro DeBEE

Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis

Pion's BEE Brand Homogenizers - The Ultimate Research Tool

Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX

Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

Introduction to Pion's BEE brand high-pressure homogenizers

Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements

Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules

Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy

Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

Using NaOH and NaCl instead of KOH and KCl

Introduction to log P and log D measurement using PionT3

Measuring log P of samples that are hard to dissolve in water and octanol

The Determination of Solubility - Pion CheqSol Explained

The use of cosolvent pKa assays for poorly soluble compounds

Measurement of Extreme pKas

Solubility and Supersaturation - A Brief Introduction

Scissor N3 overview and demo

Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations

Scissor as a platform for the analysis of non-protein subcutaneous formulations

Understanding excipient effect in vitro using the Pion Scissor

Considerations on the Controlled Release of Injectable Insulin Using Scissor

Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules

How to Achieve Efficient & Consistent Particle Size Reduction e-book

Homogenization For Cannabis e-book

Advantages of BEE Homogenizers for the Pharmaceutical Industry e-book

7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book

Reversal of IDO-mediated cancer immune suppression

Control of Oral Bioavailability by Particle Sizes

Method for preparing propofol emulsion for vascular injection

Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment

Nanoparticle Formation

DeBEE 4000

Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools

Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.

Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride

MiniDeBEE

Nano DeBEE

DeBEE 2000

Dissolution Testing

PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root

Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

Penetration Enhancer Effect of Sucrose Esters

Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies

Drug Permeation in Skin PAMPA and Franz Cell Model

In Situ Solubility and Dissolution of Concentrated Solutions

Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model

Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores

Nanoparticle Formulation of Gresiofulvin

Universal Potentiometric Sensors Protein Binding

In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C

Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials

Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

Evaluation of Optimized Caco-2 Permeability Measurements

Developing Skin PAMPA for Transdermal Patches

Supersaturation and Transmembrane Flux of Meloxicam

Universal Potentiometric Sensors Food Matrixes

Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder

Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies

Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration

Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

Skin-PAMPA: Fast Prediction of Skin Penetration

Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions

In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds

Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen

Dissolution and Precipitation Monitoring of Crystalline Salts

Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method

Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media

Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

Novel HT Method for Parallel Excipient/Vehicle Formulation Studies

Using Skin PAMPA For Transdermal Patch Testing

In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids

Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds

Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster