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Subcutaneously administered biopharmaceuticals

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Subcutaneously administered biopharmaceuticals

Poster

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Scissor subcutaneous injection site simulator mimics the human body conditions to understand how formulation influences the behavior of a biotherapeutic.

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Dissolve Macro Orange

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Subcutaneously administered biopharmaceuticals

Poster

Purpose A novel in vitro method for predicting how the characteristics of the subcutaneous tissue may influence the post-injection stability and diffusional properties of subcutaneously administered biopharmaceuticals has been developed. Scissor subcutaneous injection site simulator mimics the human body conditions and allows to understand how a formulation influences the behaviour of a biotherapeutic in the subcutaneous (SC) injection site. This allows to expedite the identification of lead formulations with optimal absorption properties following injection and facilitating rational formulation design.

Poster

Dissolve Macro Orange
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Subcutaneous Injection Site Simulator Assay
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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Dissolution Testing
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PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
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Penetration Enhancer Effect of Sucrose Esters
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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
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Drug Permeation in Skin PAMPA and Franz Cell Model
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In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
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Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
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Nanoparticle Formulation of Gresiofulvin
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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
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Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
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Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
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Evaluation of Optimized Caco-2 Permeability Measurements
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Developing Skin PAMPA for Transdermal Patches
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Supersaturation and Transmembrane Flux of Meloxicam
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Universal Potentiometric Sensors Food Matrixes
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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
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Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
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Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Poster
Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
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Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Poster
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Poster
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Poster
Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
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