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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

Poster

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De-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles.

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Dissolve Macro Orange

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

Poster

The goal of this study was to develop a method of de-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles but also to quantify theconcentration of nanoparticles present in suspensions.interplay between dissolution, solubility and permeability.

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