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The timeframe of supersaturation and potential precipitation events may have profound effects on bioavailability. The aim of this study was to develop a practical, easily standardized and predictive in vitro dissolution method to monitor powder/formulation dissolution and concomitant precipitation processes in biorelevant media dynamically being changed from simulated gastric to simulated intestinal fluid. The importance of such API-sparing, two-stage, in vitro microdissolution tests to study drug-drug interaction in the case of pH-modifying agents was reported recently.
