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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

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Dissolve Macro Orange

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Publication

The objective was to investigate the applicability and limitations of an approach for estimating particle size from powder dissolution measurement using as little as 50 microg of sample in 1 ml of buffer solutions. The powder dissolution profiles of five sparingly-soluble drugs (hydrochlorothiazide, phenazopyridine hydrochloride, 2-naphthoic acid, indomethacin, and dipyridamole) were evaluated with a novel biexponential spherical particle equation and also the Wang-Flanagan spherical particle non-sink equation

Publication

Dissolve Macro Orange
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