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Biphasic dissolution studies: Impact of concentration and particle size on partition rate

Biphasic dissolution studies: Impact of concentration and particle size on partition rate

Poster

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partition rates were measured at concentrations above and below its amorphous solubility and solid dispersions of API of two different particle sizes were created in order to investigate dissolution-limited aspects of drug absorption
Biphasic dissolution studies: Impact of concentration and particle size on partition rate

Poster

This application note discusses two biphasic studies of felodipine. In the first, partition rates were measured at concentrations above and below its amorphous solubility to understand the impact of different dose levels on absorption. In the second, solid dispersions of API of two different particle sizes were created in order to investigate dissolution-limited aspects of drug absorption. Experiments were performed using inForm, an instrument for biorelevant solubility and dissolution testing.

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