High vs. Low Pressure Homogenization: Which Is Better?

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Deb Shechter
Feb 19, 2016
min read
High vs. Low Pressure Homogenization: Which Is Better?High vs. Low Pressure Homogenization: Which Is Better?High vs. Low Pressure Homogenization: Which Is Better?

A huge proportion of the homogenizers on the market are termed high-pressure. This indicates that the maximum operating pressure is significantly higher than that of other powerful mixing tools. However, it is infrequent to hear about low-pressure homogenization. Although less well-known, low-pressure homogenization has a distinct role within the science industry. Here we analyze the differences between high- and low-pressure homogenization, addressing the question of which is better.

Both high- and low-pressure homogenizers function as mixers that reduce particle size, albeit in a somewhat different way. High pressure homogenizers are typically equipped with valves or nozzles, which have openings of <0.35 mm and help to stabilize pressure fluctuations. The pressure imparted on a product is largely determined by pump pressure or flow diversion. Low pressure homogenizers also contain a valve, but in this case fluid velocity is incremented, which reduces overall pressure. (1) In terms of uses and applications, high-pressure homogenization is more widely utilized than low-pressure homogenization. For example, pharmaceutical tablet coatings, vaccinations, and creams require high-pressure particle size reduction and most milk products undergo high-pressure homogenization to prevent separation of layers. Additionally, this method is required for numerous products from the chemical and biotechnology industries. In contrast, low-pressure homogenization has a significant role in the treatment of sludge at wastewater plants (2) and for some food/beverage products.

Ultimately, in the case of low vs. high pressure homogenization, each might be better under different circumstances. As a laboratory, having access to both pressure options will optimize your productivity. Many of the higher quality high-pressure homogenizers on the market offer customizable options; with the easy turn of a dial, forces such as cavitation, shear, and importantly, pressure, can be adjusted. By acquiring a high-pressure homogenizer with low-pressure customizability, you can get the best of both worlds.

BEE: The Homogenizer Advantage

As you work to determine which high-pressure homogenizer brand and model will be best suited for your laboratory, begin the search with Pion's BEE brand Technology. We are globally recognized among laboratory managers and researchers for our high quality products and excellent customer support. Cell lysis and particle size reduction are two of a variety of applications for Pion homogenizers; nano/micro emulsions, lipids, suspensions, and dispersions are also easily achievable.

Importantly, Pion's homogenizers can achieve consistent particle sizes at or below 100 nm, a key benefit for products that require smaller droplet sizes. Additionally, the homogenizer processes can be controlled to suit your product, which will allow you to customize to your cell type. And finally, the equipment is easy to use, produces higher yield in less time, and achieves results that are reproducible and scalable.

Learn more about how Pion homogenizers can improve your experimentation by checking out our high pressure homogenizers.

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