Laboratory BEE High Pressure Homogenizers
How do our laboratory homogenizers help our R&D customers achieve success?
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
BEE technology exceeds the capabilities of conventional homogenizers and microfluidizers enabling researchers to extend experimental boundaries
Process pressure up to 45,000 PSI (3100 Bar) pushes the limits of size reduction beyond accepted standards, further enhancing bioavailability, maximizing solubility and improving process efficiency
More experimentation options and capabilities for particle size reduction (micronization,) liposomes, emulsions, dispersions, and cell lysis. No-cost reconfiguration of the EC, optimize one application or pivot to a different project.
A radical departure from other equipment. Achieve reference formulation equivalence with a more efficient process, reducing manufacturing costs. Guaranteed scale-up from lab to process scale systems
Patented Emulsifying Cell (EC) that allows individual control over the 3 separate homogenization forces: Shear, Cavitation and Impact
Cell Disruption
Cell disruption is an example where optimum results might be reached immediately. With the turn of the dial, a more gentle process might be used for mammalian cells or perhaps a more intense process created for lysing plant cells.
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Particle size reduction
For particle size reduction of emulsions and dispersions, initial results may match or exceed that of other equipment. Unmatched experimentation capabilities may be the key to the most effective mixing process, making the difference between adequate and remarkable results. Remarkable results for new innovations, improve existing products, and more efficient manufacturing.
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Laboratory BEE High Pressure Homogenizers
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