PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
The highest processing energy in a bench-top unit for your product formulations
Air-powered unit
Achieve industry-leading results for cell lysis, nanoemulsions and dispersions, and particle size reduction.
Same level of experimentation capabilities as our electro-hydraulic units
Features
Operating pressure:
2,000– 30,000 PSI (150—2,000 bar)
Flow rate:
15 LPH (4 GPH)
- Easy cleaning and maintenance with no disassembly required
- Requires: clean, dry air; 0-35F dew point - 50 SCFM @ 100 psi for 30,000 psi (2,000 bar) max
- Minimum sample size as low as 12ml
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Industry leading results
Proven to achieve industry leading results for cell lysis, nano emulsions and dispersions, and particle size reduction:
- High-yield cell lysis
- Extend product stability
- Improve bioavailability
- Tighter particle size distribution
Applications:
- Cell Disruption
- Particle Size Reduction
- Nano / Micro Emulsions
- Nano / Micro Dispersions
- Polymers
- Liposomes
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