PrepEngine
Content Uniformity Sample Preparator Accelerate your content uniformity, analytical, mixing, and Cannabis testing sample preparation applications, create homogenous blends more easily, quickly, reliably and safely
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Accelerate your content uniformity, analytical, mixing, and Cannabis testing sample preparation applications create homogenous blends more easily, quickly, reliably and safely
Developed through collaborations with world-leading companies
Applications are unlimited and include content uniformity, analytical techniques, biological material, Cannabis, pigments, traditional medicines, food testing, and mixing applications.
A compact benchtop design that incorporates 1, 2, and 10 individually powered, high-output stirring stations which can prepare content uniformity samples up to 90% faster than conventional methods.
Sample preparation and content uniformity
PrepEngine, a flexible, productive life science processing platform newly added to the Pion portfolio for in vitro drug characterization, along with high-performance monitoring equipment for the lab environment.
These capabilities will help customers access richer, more relevant data to accelerate drug development and minimize reliance on in vivo studies.
Two Square Science’s technology directly complements Pion’s existing portfolio for dissolution testing, physicochemical analysis, sample preparation, and other in vitro measurements. PrepEngine is a simple to use, modular solution that allows users to extract materials, mix and lyse samples as required prior to analysis. It offers the ability to easily mix, match and reorder sample preparation processes to establish and automate an optimal, highly efficient solution.
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Features
Ultra-fast sample preparation
Including assay, impurity, and content uniformity applications. Up to 90% faster than conventional methods.
1, 2, 10 Individually powered stations Individually activated, high-power stirring stations maximize productivity and significantly increase sample prep throughout.
Adjustable speed and time
The speed is adjustable from 500 to 6000 rpm with user-defined time cycles.
Reliable and consistent results
The sample results are fast, reliable and consistent from test to test.
Preptube for single or multi-use
Preptubes are clear polypropylene with SS blade and include a polypropylene septa & cap. Available sizes include 50 ml, 250 ml, and 500 ml. Also available in Amber for light-sensitive dosage forms. To eliminate the possibility of carryover and cross contamination, Pion recommends single-use; however, a single Prep Tube for wet extraction can be used for a maximum of five (5) x 10-minute tests.*All tests are application specific.
Cannabis sample preparation
Dedicated sample preparation station for dry homogenizing, dry grinding & wet extraction of cannabis, hemp, and other plant material.
Low-cost, single-use PrepTubes designed specifically for dry homogenizing & grinding
PrepEngine
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