Introduction to log P and log D measurement using PionT3

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Jan 16, 2024
min read
Introduction to log P and log D measurement using PionT3

In drug development, log P refers to the logarithm of the partition coefficient. The partition coefficient is a measure of the distribution of a compound between two immiscible phases, usually octanol and water. It indicates the lipophilicity or hydrophobicity of a compound, which is an important property in drug design and development.

The log P value is calculated by taking the ratio of the concentration of a compound in octanol to its concentration in water and then taking the logarithm of this ratio. It is a parameter used to predict the compound's ability to cross biological membranes, as most biological barriers are lipid-based.

The log P value is utilized during various stages of drug development, including drug discovery, lead optimization, pharmacokinetics, and formulation. It helps in assessing a compound's absorption, distribution, metabolism, and excretion (ADME) properties, as well as its potential for bioavailability and therapeutic efficacy.

By considering log P values, researchers can prioritize compounds that have suitable lipophilicity profiles for optimal drug delivery and target interaction. It also assists in predicting potential challenges in solubility, bioavailability, and toxicity for a molecule, aiding in decision-making during the drug development process.

Learn more by checking out our application note, Introduction to log P and log D measurement using PionT3.

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