What Role Do Homogenizers Play in the Pharmaceutical Manufacturing Process?

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David Shechter
Nov 16, 2016
min read
What Role Do Homogenizers Play in the Pharmaceutical Manufacturing Process?

The mechanical process where partciles are divided into microscopic sizes, is known as homogenization. It can also be referred to as micronization or cell fractionation. This process is completed under conditions of intense stress and extremely high pressures – up to over 20,000 psi in some applications. The process of homogenization is a critical one – one used in a variety of industries, including food, dairy, cosmetic, biotech, and pharmaceutical industries. Homogenization – particularly pharmaceutical homogenization – results in an improvement of product stability, shelf life, product cost, and taste. Homogenization represents a marked improvement over other dispersion methods, such as stirrers, colloid mills, sonicators, or rotor-stator devices.

Role of Homogenizers

The role that homogenizers play in the pharmaceutical manufacturing process is an important one. With homogenization comes a smaller particle size and more even distribution of critical active ingredients. For topical pharmaceutical products, such as anesthetic creams and other topical ointments, this allows for these medications to absorb more readily into the skin, thanks to the increased surface area of the particles – another effect of successful homogenization. In the pharmaceutical industry, this translates to efficient use and even distribution of expensive active ingredients, thus reducing overall costs while increasing overall efficacy.

Homogenizers also play an important role in other pharmaceutical products, such as medicinal syrups, capsules, antibiotics, and a variety of other medications taken internally. The high pressure, turbulence, and impact during the homogenization process work together to make these types of pharmaceutical products stable, clinically effective, and cost effective as well.

What Pion Has to Offer

Pion's BEE brand offers a wide variety of homogenizers to meet both small and large-scale production needs in laboratory, pilot plant, and industrial settings. For laboratory use, our Micro DeBEE, Nano DeBEE and Mini DeBEE systems offer a consistent, reliable, and repeatable process for a number of applications, including cell disruption, particle size reduction, nano and micro emulsions, and dispersions.

For larger-scale homogenization, our pilot plant and industrial homogenizers offer high capacity particle size reduction for micro and nano emulsions and particles. These high pressure homogenizers are designed for cGMP manufacturing, and are used in a variety of industries, including pharmaceutical, life sciences, food, and cosmetic products.

Contact us today to discuss the benefits our homogenizers can bring to manufacturing your company’s products.

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