Homogenization is defined as the process of reducing the particle size of an object. A number of industries utilize this method to optimize their finished product: pharmaceutical, biotech, cosmetic, and food. And while homogenization itself is a relatively simple concept to understand, there are many variations of the technique, all dependent on the type of object that is being reduced in size. Cell homogenization, for example, involves the reduction of cell particle sizes. Another type of homogenization is tissue homogenization. What is tissue homogenization? When are tissues homogenized? And what is the best equipment to use for tissue homogenization? Continue reading for the answers to all of those questions, as well as information on the homogenization equipment offered by Pion.
Tissue Homogenization – What is it?
Tissue homogenization is a process, often used in the biotech industry, used to prepare tissue samples for further study, research, or development. The process involves the lysing – or breaking apart – of cells in order to release their contents. The type of cell being lysed often dictates the homogenization device or technique that is used to complete the task.
Manual Disruption
Tissue cells can be homogenized using a number of manual disruption techniques. One method involves running the tissue cells through a blender or other mixing device to create uniform, small cells. Cell walls can also be disrupted through the use of a mortar and pestle. Yet another technique involves the use of chemicals to rupture the cell walls. Through any of these techniques, the tissue cells can then be further processed in a centrifuge to separate them and extract the desired components.
High Pressure Homogenization
High pressure homogenization can also be utilized to homogenize tissue cells. With this technique, multiple forces are used to disrupt the cell walls: Turbulence, cavitation, shear, and impact. High pressure homogenization allows for these forces to be used simultaneously to produce the best end result, even with delicate tissues.
BEE International
Pion's BEE brand offers a number of high quality, high pressure homogenizers to achieve your goals. Our homogenizers utilize the mixing forces of cavitation, turbulence, shear, and impact, and process intensity can be adjusted with the simple turn of a dial. With our homogenizers, you will reap the benefits of our process, which includes:
- Tighter distribution of smaller particles
- Maximum particle size reduction in fewer passes
- Increased manufacturing efficiency and reduced cost
To learn more about our line of homogenizers, as well as how we can help you achieve your manufacturing goals, please contact us today.
