The Benefits of a Laboratory Homogenizer For Particle Size Reduction

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David Shechter
Jan 13, 2016
min read
The Benefits of a Laboratory Homogenizer For Particle Size Reduction

The pharmaceutical, biotechnology, chemical, and food industries depend on particle size reduction. Its uses are varied and include drug delivery, improving the biological availability of medicine, breaking down complex polymers, and many more. While multiple particle reduction methods exist, mixing with a laboratory homogenizer is preferred. Read below to learn about the benefits of laboratory homogenizers specifically for particle size reduction.

Consistent & Uniform Output

The ability of a particle size reduction technique to achieve consistent and uniform product output speaks directly to its performance. Use of a laboratory homogenizer over other mechanical or non-mechanical methods enhances these qualities. In the pharmaceutical industry, for example, the product can be incorporated into anesthetics, inhalants, injectables, or tablets. These drugs will have higher bioavailability, solubility, and stability than those with less consistent and uniform output.

Cost Efficient

As compared to other particle size reduction methods, homogenization is impressively cost-efficient. There are three key factors that contribute to this ideal quality:

  1. Fewer passes, which reduces costs by minimizing production time and using fewer reagents. While many laboratory homogenizers require 3-4 passes to achieve a uniform and consistent product, some high-quality models require only 1-2 passes.
  2. Easy to clean, which allows users to maintain parts and prevent costly replacement.
  3. Materials can be reused, such as probes, vessels, and beads. Batch cleaning or autoclaving will sufficiently sterilize most products.


The translatability of a method or system to larger sample sizes is key for researchers in the experimental stages of a product that they hope to bring to manufacturing. Because particle size reduction is key to the synthesis of many products, it is important that this technique be optimized on equipment that will allow for it to be scaled. Laboratory homogenizers are ideal in both their customizability for process optimization and scalability for manufacturing. Some companies produce laboratory homogenizers in addition to pilot-plant and industrial homogenizers, so if your process works on the laboratory homogenizer it will be guaranteed to also work on the larger-scale equipment.

A product’s ability to have its intended effect can be attributed to a wide variety of factors. In particular, particle size is a high-impact factor that researchers across industries should consider. The first step in manufacturing a high-quality product is obtaining equipment that will support its synthesis. One such example is the high-pressure BEE homogenizer by Pion. Our products are trusted by researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions. Importantly, this equipment can achieve consistent particle sizes at or below 100 nm, a key benefit for researchers & corporations that synthesize products requiring particle size reduction.

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