Pharmaceutical Syrups & Cough Mixtures: 4 Reasons to Homogenize

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Jen Hug
Mar 16, 2016
min read
Pharmaceutical Syrups & Cough Mixtures: 4 Reasons to Homogenize

Cough mixtures and syrups are staples in the pharmaceutical industry, particularly for children and other individuals who cannot swallow tablets. Because they are liquids, however, these products face unique challenges in their production process. The mixing technology chosen for a given product will have a significant impact on its effectiveness and overall quality; here we analyze specific ways that the homogenization process will contribute to production of a high quality and effective syrup or mixture.

  • Increased chemical stability

Most cough mixtures and pharmaceutical syrups are comprised of emulsions, which are mixtures of two immiscible liquids. Critical to the drug’s ability to function is its chemical makeup, specifically around its ability to remain a homogenous mixture. High pressure homogenization not only emulsifies, but also stabilizes the particles to prevent separation of layers.

  • Smooth and agglomerate-free mixture

Syrups and mixtures typically require at least one thickening agent to achieve the ideal consistency. However, these ingredients can cause agglomeration that cannot be dispersed by conventional mixtures. High pressure homogenizers, however, use mechanical forces along with pressure to achieve a smooth and uniform product, so can overcome this problem.

  • Preservation of active ingredients and improved bioavailability

Some mixing processes use heat, which can be effective when paired with appropriate products. However, the active ingredient in pharmaceutical mixtures can be damaged by heat, so temperature change should be avoided when possible. As indicated above, high pressure homogenization uses high pressure and mechanical forces instead of heat, which preserves the active ingredient and increases its bioavailability in vivo.

  • Flexibility in particle size

Although smaller particle size is oftentimes preferred, it is a uniform product that actually creates consistency in patient outcomes. This is particularly important if the patient purchases product from more than one batch of syrups or mixtures. Most pharmaceutical mixtures are comprised of nanoemulsions; regardless of the particle size comprising your product, it is important to achieve consistent particle size across all batches.

Pion: The Homogenizer Advantage

Are you in need of equipment to support synthesis of a pharmaceutical product? Pion's BEE brand technology is trusted by pharmaceutical researchers and lab managers around the world. We deliver an array of key benefits, such as production of nano/micro emulsions and dispersions and lipids and suspensions; these can be used for applications such as injectables, targeted drug delivery, inhalants, time release, anesthetics, and importantly, vaccinations.

In addition, we have extensive experience in the challenges that our pharmaceutical customers face as they transition from concept, through to R&D, clinical trials, all-important FDA approval, and finally to manufacturing.

Learn more here.

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