How a High Pressure Homogenizer Benefits Pharmaceutical Creams

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Deb Shechter
May 2, 2016
min read
How a High Pressure Homogenizer Benefits Pharmaceutical Creams

Modern-day medicine, as you know, has grown leaps and bounds from what it once was even 100 years ago. Pharmaceutical treatments abound, from pills to injections to creams. Creams, a non-invasive mode of drug delivery, are used to treat a variety of conditions, mostly skin-related (e.g. rashes, stings, and fungal infections). As its production method largely dictates its effectiveness, here we will look at some benefits of using high pressure homogenization to create pharmaceutical creams.

Forms Emulsions

The intensive mixing achieved by homogenizers is ideal for forming emulsions, which are comprised of two immiscible liquids. A high proportion of most pharmaceutical creams is made up of emulsions, so pharmaceutical companies are willing to invest in machinery that will make this ingredient effectively. High pressure homogenizers, in particular, have the ability to reduce particle size more significantly than most mixers, due to both the high pressure and multiple mechanical forces acting on a sample; the droplets therefore have more surface area, which is advantageous for optimal function.

Promotes Chemical Stability

Most people can think of a cream, lotion, or other household ingredient that needs to be mixed before each use because the two phases separate. Not only is it annoying, but it can also have a negative impact on the product’s ability to do its job. High pressure homogenization, due to its high power, promotes chemical stability for a longer product shelf life and higher level of function.

Consumer Benefits

Consumers who use pharmaceutical creams produced by high pressure homogenization can expect numerous physiological benefits. For example, the emulsions within pharmaceutical creams improve bioavailability and dissolution rates, especially for poorly water-soluble drugs. Additionally, the manufacturer can program a cream for slow or rapid drug release, depending on the specific condition being treated.

Pion: Equipment For Efficient Emulsion Production

As you either embark on, or continue along, the process of producing emulsions for pharmaceutical creams, your product’s success may depend on the equipment used to make it. High pressure homogenization is the most common method for producing emulsions, because of both its powerful mixing process and its cost/time effectiveness. The homogenizer will shear fluid by forcing it through a restrictive valve, forming a high-quality emulsion. Pion's BEE brand technology is trusted by lab managers and scientists around the world for their high-pressure homogenizers. They offer homogenizers that are both high-quality and reliable, and which can help your lab produce nano/micro emulsions, dispersions, and suspensions to be incorporated into your pharmaceutical cream. Contact us to learn more about our products.

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