4 Key Benefits of Fine Tuning the Particle Size Reduction Mixing Process

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Deb Shechter
Sep 3, 2015
min read
4 Key Benefits of Fine Tuning the Particle Size Reduction Mixing Process

Manufacturers in different areas, such as the biotech, pharmaceutical, chemical, food and cosmetic industries, need to break particles apart in a controlled manner in order to achieve their desired end product.

However, in other to achieve this critical business objective in a cost effective and efficient manner, it is essential for manufacturers to have the ability to fine tune the particle size reduction mixing process, because it enables these 4 key benefits:

1. Maximized Particle Size Reduction  

Manufactures want to achieve the smallest particle size possible. Fine tuning allows them to consistently achieve this goal, which in turn enables important advantages such as improved bioavailability, targeted drug delivery, and more efficient downstream processing.

2. Tighter Distribution of Particles

In addition to particle size reduction, manufactures must also achieve the tightest distribution possible – which is another benefit that is enabled through fine tuning the process. Tighter distribution leads to greater product stability, a longer shelf life, optimized particle characteristics (e.g. reactivity, gloss, etc.), and uniform product features (e.g. temperature, quality, etc.).  

3. Optimized Manufacturing Efficiency

Fine tuning the particle size reduction process also allows manufacturers to get the smallest and tightest possible particles in as few passes as possible, which makes the process more cost effective and efficient. This is a vital consideration, given how important it is for researchers and manufacturers to demonstrate ROI and thus receive sufficient budgets to carry out their important work.

4. Consistent Results

Lastly, fine tuning enables manufacturers to achieve repeatable, consistent and precisely controlled results. This helps reduce costs, and is also essential for scalability. In fact, without consistent results, it would be extremely risky and likely financially unjustifiable to scale up to clinical trials or product development.

Problems with Conventional Technologies

Conventional technologies do not allow manufacturers to fine tune the particle size reduction process, which leads to excess risk, costs and time, plus creates frustration – particularly when the goal is to replicate laboratory results on a clinical trial or production volume scale.

The Pion Solution

Fortunately, Pion’s proprietary technology is modular, which enables manufacturers to leverage all mixing forces (turbulence, cavitation, shear, and impact), yet while fine tuning the process to achieve the best possible results for a given product. For example:

  • A laminar flow can replace turbulent premixing  
  • Adjusting the nozzle size allows cavitation to be intensified or lessened  
  • Shear process time can be made longer or shorter
  • Impact can be maximized via a reverse flow setup
  • Process intensity can be reduced or increased  

Discover why our technology is used by researchers and manufactures around the world here.

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