3 Benefits of High Pressure Homogenization for Nanoparticles

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Deb Shechter
Jan 25, 2016
min read
3 Benefits of High Pressure Homogenization for Nanoparticles

Nanoparticle research is widespread and of high interest to the scientific community. With uses such as gene delivery, protein detection, tissue engineering, drug delivery systems, and fluorescent biological labels, it is no wonder that scientists continue to probe further.‍

Nanoparticle preparation can be accomplished via multiple methods, yet high pressure homogenization is the most common, and with good reason. Keep reading to learn about the benefits of high pressure homogenization for nanoparticle synthesis.

  • Customizable Forces to Optimize Results

Unlike other mixing equipment, high pressure homogenizers combine both pressure and mechanical forces to achieve a uniform and consistent product. Mechanical forces can include turbulence, shear, cavitation, impact, and process intensity. High quality homogenizers offer the option to easily adjust these forces, which allows the researcher to optimize product results. This factor is key to achieving a functional nanoparticle, as well as for any other product made via high pressure homogenization.

  • Hot & Cold Homogenization Options

High pressure homogenization can be accomplished using either hot or cold temperatures. Hot homogenization uses heat above the lipid melting point to to obtain an aqueous phase. However, hot homogenization has significant drawbacks, particularly in the drug delivery arena; these include heightened product degradation, drug loss from the aqueous phase, and uncertain lipid transitions. In contrast, cold homogenization was developed to overcome the drawbacks of hot homogenization and is conducted with solid lipids. Because each method is preferable for different circumstances, having the option to select one or the other allows researchers to achieve optimal product results.

  • Smaller Particle Sizes Than Other Equipment

Because of the significant amount of pressure imparted on the product, alongside the actions of mechanical forces, high pressure homogenizers are unique from other mixing equipment. These forces allow for synthesis of smaller particle sizes, which confers increased nanoparticle surface area and bioavailability. Particularly for drug delivery systems and other pharmaceutical purposes, these factors are key to an effective treatment.

Pion's BEE Homogenizers: Homogenizers for Nanoparticle Production

Production of nanoparticles involves high-pressure emulsification, typically through homogenization. Homogenization is the preferable method due to its ability to reduce particle sizes more significantly than other blending/emulsification methods. The first step in synthesizing a high quality nanoparticle is purchasing equipment that will achieve small and consistent particle size distribution. One such example is the high pressure homogenizer by . Our products are trusted by pharmaceutical researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions; importantly, this equipment can achieve consistent particle sizes at or below 100 nm, a key benefit for researchers & corporations that synthesize pharmaceutical products.

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