Low Volume Dissolution-Absorption testing
Utilizing the Pion Rainbow for in-situ real-time measurement
Simultaneous assessment of drug substance
Combine Dissolution and Absorption measurements into a single assay
The impact of excipients on drug behavior when conducting these simultaneous dissolution-absorption studies provides an understanding of the complex interplay between solubility, permeability, and dissolution rate in-vitro and establishes the MicroFLUX as a valuable tool for ranking in vivo outcomes.
Fiber-optic UV probes are positioned in both the donor and receiver compartments allowing real-time dissolution and absorption concentration monitoring in both chambers. Concentration monitoring is enabled by connecting the fiber optic UV probes from the Rainbow Dynamic Dissolution Monitor® instrument. AuPRO software contains dissolution and absorption curve modeling tools to calculate dissolution rate and flux parameters without the need to external data processing or calculation.