MiniFLUX
An in vitro analytical platform for dissolution and flux measurements of whole dose formulations using biorelevant volumes
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Complete solution from Pion: In vitro Flux technology with Rainbow R6 real time concentration monitoring integrated into Pion miniDT 250mL platform
Simultaneously measuring concentration on both sides of a bio-mimetic membrane improves the assessment of the absorption potential and provides more realistic IVIVC modeling.
Biomimetic separation barrier utilizing Pion validated PAMPA permeability membrane.
Biorelevant environment: Dissolution volume varies from 130 to 250mL, mimicking gastro-intestinal volumes and matching FDA requirements for BCS solubility tests.
Dissolution Media: miniFlux is suitable for Pion’s standard media change protocol for FaSSIF and for FeSSIF as well.
Using miniFlux with 250mL donor volume, excellent comparison can be achieved between miniFLux and BioFlux.
miniFLUX: Advancing IVIVC with Expertise in Dissolution and Permeability
This innovative apparatus is used in conjunction with the miniDT 250mL dissolution systems and allows for FLUX testing of finished drug products. When coupled with Pion’s in situ fiber optic monitoring systems, the amount of data now available from the test is unsurpassed.
Simultaneously determine the complex effect of formulation on dissolution, solubility and permeability of API. Accurately Predict Pharmacokinetic outcomes earlier.
THE PION PAMPA ADVANTAGE
Lorem ipsum dolor sit amet, consectetur adipiscing elit.
In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
MiniFLUX
Related Resources
Locate a
Distributor
