Simultaneously measuring concentration on both sides of a bio-mimetic membrane improves the assessment of the absorption potential and provides more realistic IVIVC modeling.
Biomimetic separation barrier utilizing Pion validated PAMPA permeability membrane.
Biorelevant environment: Dissolution volume varies from 130 to 250mL, mimicking gastro-intestinal volumes and matching FDA requirements for BCS solubility tests.
Dissolution Media: miniFlux is suitable for Pion’s standard media change protocol for FaSSIF and for FeSSIF as well.
Using miniFlux with 250mL donor volume, excellent comparison can be achieved between miniFLux and BioFlux.
Simultaneously determine the complex effect of formulation on dissolution, solubility and permeability of API.
Accurately Predict Pharmacokinetic outcomes earlier