MiniDISS Profiler
Rainbow R6 miniDISS Profiler Configuration
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Rainbow R6 miniDISS Profiler Configuration
Rainbow in situ Fiber Optic UV monitoring system.
Designed for biorelevant media volumes from 100-250mL.
Ideal for measuring high-potency API or when low concentrations are expected.
Applications
- Formulation development
- Oral dosage form dissolution for sink and non-sink conditions
- Pediatric drug products development
- High potency drug products testing
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Features
- Flexibility in small volume testing
- Eliminates time-consuming swap out and revalidation requirements when switching from large to small volumes
- Eight-position stirring system with interchangeable 100 ml, 150 ml or 200 ml standard vessels or 250 ml Chinese Pharmacopiea vessels
- Industry standard Rainbow technology
- Data collection of the full UV Spectra (200 - 720 nm) as fast as every two seconds
- Dip-Style Fiber Optic Probes with interchangeable path length tips
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