SCISSOR N3
Scissor N3 In Vitro Subcutaneous Injection Site Simulator
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development.
Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.
Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.
The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.
Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.
Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.
Compatible with an optional fraction collector
Gain biorelevant data about your subcutaneous sample in vitro
Coupled with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, lymphatic and systemic release data can be measured in-situ giving real-time results and enriching the data collection process.
Sample aliquots can also be collected with an additional external fraction collector to allow for offline analysis with any preferred analytical method facilitating more in-depth research.
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Formulations
The Scissor N3 is an exciting branch of the Pion technology helping users understand formulations
- Excipient screening during formulation development
- Formulation comparison
- Rank ordering formulations for candidate selection
- Investigation of drug stability upon and after injection
Extracellular matrices
ECM
A hyaluronic acid-based viscous liquid dynamically created to mimic the human subcutaneous space for 24-hour long assays for immediate release formulations.
ECM-XR
A hydrogel containing hyaluronic acid constructed to simulate the human subcutaneous space for up to a week aimed towards long-acting injectables for sustained release formulations.
SCISSOR N3
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