Nano DeBEE Gen II
Cost-Effective Benchtop Electric Unit Offers Reliable And Consistent Process For R&D
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Cost-Effective Benchtop Electric Unit Offers Reliable And Consistent Process For R&D
The most versatile benchtop homogenizer
Combines a variety of mixing tools into one advanced instrument
Select the specific combination of mixing parameters as well as adjust their intensity.
Features
Flow rate:
Nano DeBEE 45-2: 2 LPH (33 mLPM or .5 GPH)
Nano DeBEE 45-6: 6 LPH (100 mLPM or 1.5 GPH
- Modular Emulsifying Cell (EC)- more experimentation options than any other equipment
- PLC control and monitoring for easy operation
- Minimum sample size as low as 12 ml
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
The Nano DeBEE Gen II laboratory homogenizer
- Emulsification
- Particle Size Reduction
- Reaction Chemistry
- Dispersion
- Suspension
- Cell Lysis
- Liposomal Encapsulation
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