DeBEE 4000
DeBEE 4000 Manufacturing Scale Homogenizer
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Automation, Compliance and Production Capacity Ultra-High Pressure Homogenizer
Top-of-the-line series
Offering manufacturing scale capacity
Full plant integration and compliance with CFR 21 part 11
Innovative synchronization of multiple intensifier pumps
Flexible modular system design
State-of-the-art computerized controls for unparalleled reliability
Highest level of process controls and automation
DeBEE 4000 models are suitable for a wide range of applications, from abrasive slurries in the chemical industry to injectable drugs.
All with the highest levels of regulatory compliance and data harvesting.
Operating pressure & flow rate: DeBEE 4000 units are custom designed solutions for specific manufacturing requirements.
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Features
Max Operating pressure:
- Systems available for 10K PSI to 45K PSI
Flow rates:
- Systems available from 250 LPH to 1000 LPH (66 to 265 GPH)
- cGMP, CE, CFR 21 Part 11
- Process scaled from R&D to
- produce same results
- Proprietary synchronized
- pumping system for a constant process and a tighter distribution of end product
- results
- Hydraulically driven vertical
- intensifier pumps with slow stroke rates provide:
- Higher pressure capability
- Higher process intensity
- Lower maintenance cost
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DeBEE 4000
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