Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.
Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.
The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.
Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.
Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.
Compatible with an optional fraction collector
- Excipient screening during formulation development
- Formulation comparison
- Rank ordering formulations for candidate selection
- Investigation of drug stability upon and after injection
A hyaluronic acid-based viscous liquid dynamically created to mimic the human subcutaneous space for 24-hour long assays for immediate release formulations.
A hydrogel containing hyaluronic acid constructed to simulate the human subcutaneous space for up to a week aimed towards long-acting injectables for sustained release formulations.