Transdermal Drug Delivery
Choose your transdermal formulations quickly and effectively using in vitro data that accurately determines properties that effect drug uptake.
Historically, oral drug delivery has been the preferred route of administration by patients, avoiding the needle exposure which comes with injectable methods.
However, since the first transdermal patch was approved in 1979 , Transdermal Drug Delivery (TDD) methods have become an increasingly popular non-invasive approach to aid with patient compliance.
Transdermal formulations are targeted to penetrate through the stratum corneum and epidermis layers of the skin to reach the dermis where the active pharmaceutical ingredient (API) is systemically absorbed via dermal microcirculation. In order to penetrate the skin layers, the formulations tend to be applied topically in the form of a patch, cream or gel, but can also be delivered via microneedles to the surface of the skin.
With patient adherence to long-term medication being of upmost importance, many companies are targeting the transdermal route to ensure compliance is maintained. In order to get those formulations into the clinic, it’s crucial for scientists to understand their drug properties and formulation permeability to determine successful candidates.
Choosing transdermal drug candidates
For Scientists, one of the biggest challenges is getting the target API to permeate the skin layers to ensure the desired release is obtained.
Exploring different methods to permeate these layers and simultaneously aiming to deliver the optimum dose remains a challenge.
Understanding which excipients help or hinder the API release is essential in aiding the decision-making process. Making this information available at the earliest possible stage in development ensures that accurate informed decisions are being made about TDD formulations, aiming to eliminate late-stage failures. Pion works to make this research possible.
Pion's Solutions
From accurately determining an API logP , to testing the permeability of different cream formulations, the rich data obtained from Pion technology can help researchers to define the strengths and limitations of their drugs making research faster, effective, and more efficient.
Transdermal Drug Delivery
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