Historically, oral drug delivery has been the preferred route of administration by patients, avoiding the needle exposure which comes with injectable methods.
However, since the first transdermal patch was approved in 1979 , Transdermal Drug Delivery (TDD) methods have become an increasingly popular non-invasive approach to aid with patient compliance.
For Scientists, one of the biggest challenges is getting the target API to permeate the skin layers to ensure the desired release is obtained.
Exploring different methods to permeate these layers and simultaneously aiming to deliver the optimum dose remains a challenge.
Understanding which excipients help or hinder the API release is essential in aiding the decision-making process. Making this information available at the earliest possible stage in development ensures that accurate informed decisions are being made about TDD formulations, aiming to eliminate late-stage failures. Pion works to make this research possible.
From accurately determining an API logP , to testing the permeability of different cream formulations, the rich data obtained from Pion technology can help researchers to define the strengths and limitations of their drugs making research faster, effective, and more efficient.