Events

Simulating prodrug biotransformation in vitro-Conserving enzymatic activity within the SCISSOR N3 platform

Details

start

September 4, 2025

at

11:00 am

ends

September 4, 2025

at

12:00 pm

cost

Webinar

location

Zoom

website

Simulating prodrug biotransformation in vitro-Conserving enzymatic activity within the SCISSOR N3 platform
Simulating prodrug biotransformation in vitro-Conserving enzymatic activity within the SCISSOR N3 platform

Traditional  dissolution methods do not include bioactive components within their  methodologies. Although helpful for the dissolution of soluble tablets and  other classes of APIs, prodrugs require active enzyme in order to exhibit  their mechanism of action (aka biotransformation). We have previously  developed an in vitro instrument, termed the subcutaneous injection site simulator (SCISSOR),  which offers a dynamic environment to assay injectable pharmaceuticals to  overcome this barrier.

At the heart  of the SCISSOR platform lies an artificial extracellular matrix, suited for  the non-destructive suspension of biomolecules. Within this webinar we look  to describe how we conserve biorelevant enzymatic activity within the SCISSOR  N3, expanding the application space of acellular in vitro methods to  include characterizing the behavior of prodrug formulations before, during,  and after biotransformation.